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Article

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

1 Oct 2021

Abstract excerpt

Human respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections in the pediatric, elderly, and immunocompromised individuals. RSV non-structural protein NS1 is a known cytosolic immune antagonist, but how NS1 modulates host responses remains poorly defined. Here, we observe NS1 partitioning into the nucleus of RSV-infected cells, including the human airway epithelium. Nuclear NS1...

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PMID: 34644581
DOI: 10.1016/j.celrep.2021.109803

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