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Article

Mairin polarizes Macrophages into M2-phenotype and alleviates Ulcerative colitis through activating IRF4-CD5L pathway.

Biochemical pharmacology - 1 May 2026

Liu Jun, Liu Shunfei, Ma Qiannan, Xie Yilin, Zeng Xinyue, Zhang Chunyang, Guo Panhui, Gao Zhiwei, Hu Xiangpeng

Abstract excerpt

Ulcerative colitis (UC) is a recurrent inflammatory bowel disease characterized by mucosal inflammation. Recently, the incidence rate of UC increases year by year, and patients diagnosed with UC usually have the poor quality of life. The search for effective treatments of UC remains a crucial research priority. Since traditional Chinese medicine (TCM) is an important treatment for UC, the components of these TCMs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41651133
DOI: 10.1016/j.bcp.2026.117771

Genes

CD5L
EGFR
SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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