Article
[Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Dec 2007
Wang Yan, Xu Jian-Ming, Shen Lin, Xu Nong, Wang Jin-Wan, Jiao Shun-Chang, Zhang Jing-Sheng, Song San-Tai, Li Jian, Bao Han-Ying, Yang Lin, Li Fang
Abstract excerpt
OBJECTIVE: To assess the polymorphism of UGT1A gene in Chinese, and to investigate the correlation between UGT1A polymorphism and irinotecan toxicity in colorectal cancer patients. METHODS: 70 patients with advanced colorectal cancer were treated with irinotecan and 5-fluorouracil. Polymorphism a...
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