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Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization

7 Dec 2015

Abstract excerpt

Metal acquisition and intracellular trafficking are crucial for all cells and metal ions have been recognized as virulence determinants in bacterial pathogens. Virulence of the human gastric pathogen Helicobacter pylori is dependent on nickel, cofactor of two enzymes essential for in vivo colonization, urease and [NiFe] hydrogenase. We found that two small paralogous nickel-binding proteins with high content in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26641249
DOI: 10.1371/journal.ppat.1005312

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