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Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution

11 Jan 2021

Abstract excerpt

Infection of the human stomach by Helicobacter pylori remains a worldwide problem and greatly contributes to peptic ulcer disease and gastric cancer. Without active intervention approximately 50% of the world population will continue to be infected with this gastric pathogen. Current eradication, called triple therapy, entails a proton-pump inhibitor and two broadband antibiotics, however resistance to either...

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PMID: 33431861
DOI: 10.1038/s41467-020-20485-6

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