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Article

Characterization in Helicobacter pylori of a Nickel Transporter Essential for Colonization That Was Acquired during Evolution by Gastric Helicobacter Species

6 Dec 2016

Abstract excerpt

Metal acquisition is crucial for all cells and for the virulence of many bacterial pathogens. In particular, nickel is a virulence determinant for the human gastric pathogen Helicobacter pylori as it is the cofactor of two enzymes essential for in vivo colonization, urease and a [NiFe] hydrogenase. To import nickel despite its scarcity in the human body, H. pylori requires efficient uptake mechanisms that are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27923069
DOI: 10.1371/journal.ppat.1006018

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