Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational and Computational Evidence That a Nickel-Transfer Tunnel in UreD Is Used for Activation of Klebsiella aerogenes Urease.

Biochemistry - 20 Oct 2015

Farrugia Mark A, Wang Beibei, Feig Michael, Hausinger Robert P

Abstract excerpt

Nickel-containing urease from Klebsiella aerogenes requires four accessory proteins for proper active site metalation. The metallochaperone UreE delivers nickel to UreG, a GTPase that forms a UreD/UreF/UreG complex, which binds to urease apoprotein via UreD. Prior in silico analysis of the homologous, structurally characterized UreH/UreF/UreG complex from Helicobacter pylori identified a water tunnel originating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Enterobacteriaceae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Molecular Dynamics Simulation

Share to Mutagenesis

Share to Nickel

Share to Protein Conformation

Share to Urease

Source

Open in PubMed Open full text

Identifiers

PMID: 26401965
DOI: 10.1021/acs.biochem.5b00942
PMCID: PMC5453724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational and Computational Evidence That a Nickel-Transfer Tunnel in UreD Is Used for Activation of Klebsiella aerogenes Urease.PMID 26401965Read ↗

Structural insights into how GTP-dependent conformational changes in a metallochaperone UreG facilitate urease maturation.Semantic proximity Read ↗

UreE-UreG Complex Facilitates Nickel Transfer and Preactivates GTPase of UreG in Helicobacter pyloriSemantic proximity Read ↗

Structural insights into how metallochaperones UreE and UreG interact to deliver a toxic metal to ureaseSemantic proximity Read ↗

Nickel translocation between metallochaperones HypA and UreE in Helicobacter pyloriSemantic proximity Read ↗

Purification, characterization, and functional analysis of a truncated Klebsiella aerogenes UreE urease accessory protein lacking the histidine-rich carboxyl terminus.Semantic proximity Read ↗

Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori.Semantic proximity Read ↗

Nickel trafficking system responsible for urease maturation inHelicobacter pyloriSemantic proximity Read ↗

Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pyloriSemantic proximity Read ↗

The assembly of the plant urease activation complex and the essential role of the urease accessory protein G (UreG) in delivery of nickel to urease.Semantic proximity Read ↗

Exploration of urease-aided calcium carbonate mineralization by enzyme analyses of Neobacillus mesonae strain NS-6.Semantic proximity Read ↗

Novel nickel transport mechanism across the bacterial outer membrane energized by the TonB/ExbB/ExbD machinery.Semantic proximity Read ↗

The functional and catalytic landscape of urease reveals a conserved target against Helicobacter pylori.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.