Article
Novel nickel transport mechanism across the bacterial outer membrane energized by the TonB/ExbB/ExbD machinery.
Molecular microbiology - 1 Feb 2007
Schauer Kristine, Gouget Barbara, Carrière Marie, Labigne Agnès, de Reuse Hilde
Abstract excerpt
Nickel is a cofactor for various microbial enzymes, yet as a trace element, its scavenging is challenging. In the case of the pathogen Helicobacter pylori, nickel is essential for the survival in the human stomach, because it is the cofactor of the important virulence factor urease. While nickel transport across the cytoplasmic membrane is accomplished by the nickel permease NixA, the mechanism by which nickel...
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