Article
Cell-morphodynamic phenotype classification with application to cancer metastasis using cell magnetorotation and machine-learning.
PloS one - 1 Jan 2021
Elbez Remy, Folz Jeff, McLean Alan, Roca Hernan, Labuz Joseph M, Pienta Kenneth J, Takayama Shuichi, Kopelman Raoul
Abstract excerpt
We define cell morphodynamics as the cell's time dependent morphology. It could be called the cell's shape shifting ability. To measure it we use a biomarker free, dynamic histology method, which is based on multiplexed Cell Magneto-Rotation and Machine Learning. We note that standard studies looking at cells immobilized on microscope slides cannot reveal their shape shifting, no more than pinned butterfly...
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