Article
Emerging machine learning approaches to phenotyping cellular motility and morphodynamics.
Physical biology - 17 Jun 2021
Choi Hee June, Wang Chuangqi, Pan Xiang, Jang Junbong, Cao Mengzhi, Brazzo Joseph A, Bae Yongho, Lee Kwonmoo
Abstract excerpt
Cells respond heterogeneously to molecular and environmental perturbations. Phenotypic heterogeneity, wherein multiple phenotypes coexist in the same conditions, presents challenges when interpreting the observed heterogeneity. Advances in live cell microscopy allow researchers to acquire an unprecedented amount of live cell image data at high spatiotemporal resolutions. Phenotyping cellular dynamics, however, is...
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