IFNλ4 Gene Variants Are Associated with CD8+ T Cell IL-2 Response After COVID-19 Vaccination: A Preliminary Study.

doi:10.3390/biom16081111

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IFNλ4 Gene Variants Are Associated with CD8+ T Cell IL-2 Response After COVID-19 Vaccination: A Preliminary Study.

Biomolecules - 29 Jul 2026

Sanfilippo Giuseppa Luisa, Badami Giusto Davide, La Manna Marco Pio, Pizzo Mariangela, Lio Domenico, Giammanco Giovanni Maurizio, Caccamo Nadia

Abstract excerpt

Individual responses to SARS-CoV-2 vaccination vary due to viral mutations, demographic factors, and genetic background, with T-cell responses being less affected by viral variability. However, less is known about the effect of age, sex, and genetic background on the T-cell response in vaccinated subjects. In particular, the influence of interferon lambda (IFN-λ) genetic polymorphisms on vaccine-induced cellular...

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CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
COVID-19 Vaccines
Interferons
Interleukin-2
Interleukins

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SARS-CoV-2

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PMID: 42650779
DOI: 10.3390/biom16081111
PMCID: PMC13511631

Genes

CD4
IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.