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Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly

16 Nov 2021

Abstract excerpt

Inner dynein arm (IDA), composed of a series of protein complex, is necessary to cilia and flagella bend formation and beating. Previous studies indicated that defects of IDA protein complex result in multiple morphological abnormalities of the sperm flagellum (MMAF) and male infertility. However, the genetic causes and molecular mechanisms in the IDAs need further exploration. Here we identified two...

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PMID: 34782613
DOI: 10.1038/s41421-021-00327-5

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