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Article

A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia.

Journal of assisted reproduction and genetics - 1 Jun 2020

Ni Xiaoqing, Wang Jiajia, Lv Mingrong, Liu Chunyu, Zhong Yading, Tian Shixiong, Wu Huan, Cheng Huiru, Gao Yang, Tan Qing, Chen Beili, Li Qiang, Song Bing, Wei Zhaolian, Zhou Ping, He Xiaojin, Zhang Feng, Cao Yunxia

Abstract excerpt

BACKGROUND: Asthenoteratospermia with multiple morphological abnormalities in the sperm flagella (MMAF) is a significant cause of male infertility. WDR19 is a core component in the IFT-A complex and has a critical role in intraflagellar transport. However, the role of WDR19 mutations in male infertility has yet to be examined. METHODS AND RESULTS: We performed whole exome sequencing (WES) for 65...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32323121
DOI: 10.1007/s10815-020-01770-1
PMCID: PMC7311615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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