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Article

Gene of the month: H3F3A and H3F3B.

Journal of clinical pathology - 1 Jan 2022

Aldera Alessandro Pietro, Govender Dhirendra

Abstract excerpt

H3F3A and H3F3B genes are located at 1q42.12 and 17q25.1, respectively, and encode identical H3.3 core histone proteins which form part of the histone hetero-octamer complex. Histones function by packaging DNA into small units, the nucleosome, and are highly susceptible to epigenetic post-translational modification. H3 K27 mutations have been shown to inhibit the polycomb repressive complex 2, which is normally...

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Identifiers

PMID: 34782425
DOI: 10.1136/jclinpath-2021-207751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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