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Article

Generation of HLA Universal Megakaryocytes and Platelets by Genetic Engineering

27 Oct 2021

Abstract excerpt

Patelet transfusion refractoriness remains a relevant hurdle in the treatment of severe alloimmunized thrombocytopenic patients. Antibodies specific for the human leukocyte antigens (HLA) class I are considered the major immunological cause for PLT transfusion refractoriness. Due to the insufficient availability of HLA-matched PLTs, the development of new technologies is highly desirable to provide an adequate...

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Identifiers

PMID: 34777386
DOI: 10.3389/fimmu.2021.768458

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