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Generation and characterization of HLA-universal platelets derived from induced pluripotent stem cells

21 May 2020

Abstract excerpt

Platelet demand has increased around the world. However, the inadequacy of donors, the risk of transfusion-transmitted infections and associated reactions, and the refractory nature of platelet transfusions are among the limitations of allogeneic platelet transfusions. To alleviate these problems, we propose generating platelets in a laboratory that do not induce alloimmunity to human leukocyte antigen (HLA)...

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PMID: 32439978
DOI: 10.1038/s41598-020-65577-x

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