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Article

CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes.

Blood - 11 Feb 2016

Zhang Nanyan, Zhi Huiying, Curtis Brian R, Rao Sridhar, Jobaliya Chintan, Poncz Mortimer, French Deborah L, Newman Peter J

Abstract excerpt

Human platelet alloantigens (HPAs) reside on functionally important platelet membrane glycoproteins and are caused by single nucleotide polymorphisms in the genes that encode them. Antibodies that form against HPAs are responsible for several clinically important alloimmune bleeding disorders, including fetal and neonatal alloimmune thrombocytopenia and posttransfusion purpura. The HPA-1a/HPA-1b alloantigen...

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Identifiers

PMID: 26634302
DOI: 10.1182/blood-2015-10-675751
PMCID: PMC4751021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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