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Article

Generation of HLA-Universal iPSC-Derived Megakaryocytes and Platelets for Survival Under Refractoriness Conditions

1 Jan 2016

Abstract excerpt

Platelet (PLT) transfusion is indispensable to maintain homeostasis in thrombocytopenic patients. However, PLT transfusion refractoriness is a common life-threatening condition observed in multitransfused patients. The most frequent immune cause for PLT transfusion refractoriness is the presence of alloantibodies specific for human leukocyte antigen (HLA) class I epitopes. Here, we have silenced the expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27262025
DOI: 10.2119/molmed.2015.00235

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