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Article

Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer.

Oncology reports - 1 Jan 2013

Wang Lixin, Wang Lei, Zhang Shuping, Qu Guangbo, Zhang Daoqiang, Li Shitao, Liu Sijin

Abstract excerpt

p53 is a key tumor suppressor and a master regulator of various signaling pathways, such as those related to apoptosis, cell cycle and DNA repair. In this study, we found a pronounced cytosolic accumulation of the p53 protein in a panel of breast cancer specimens. Several mutations lead to p53 accumulation by disruption of MDM2-mediated p53 degradation. However,...

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Source

Identifiers

PMID: 23128672
DOI: 10.3892/or.2012.2121

Genes

TRAF7
TNF
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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