Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endometrial cancer may be part of the MUTYH-associated polyposis cancer spectrum.

European journal of medical genetics - 1 Jan 2022

Villy Marie-Charlotte, Masliah-Planchon Julien, Buecher Bruno, Beaulaton Clément, Vincent-Salomon Anne, Stoppa-Lyonnet Dominique, Colas Chrystelle

Abstract excerpt

The MUTYH gene encodes a DNA glycosylase that prevents G:C→T:A transversions. Patients with biallelic pathogenic germline MUTYH variants develop an adenomatous polyposis called MUTYH-associated polyposis (MAP). Endometrial cancers have been reported in patients with MAP, but the role of MUTYH loss of function in the oncogenesis remains unclear. We report for the first time a case of endometrial carcinoma with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to DNA Glycosylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Endometrium

Share to Loss of Function Mutation

Share to Mutation

Source

Identifiers

PMID: 34775073
DOI: 10.1016/j.ejmg.2021.104385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endometrial cancer may be part of the MUTYH-associated polyposis cancer spectrum.PMID 34775073Read ↗

MUTYH-Associated Polyposis: The Irish Experience>.Semantic proximity Read ↗

MUTYH-associated tumor syndrome: The other face of MAP.Semantic proximity Read ↗

Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations.Semantic proximity Read ↗

MUTYH Associated Polyposis (MAP)Semantic proximity Read ↗

Hereditary Colorectal Tumors: A Literature Review on MUTYH-Associated PolyposisSemantic proximity Read ↗

Phenotype correlations with pathogenic DNA variants in the<i>MUTYH</i>geneSemantic proximity Read ↗

[MUTYH-associated polyposis: Review and update of the French recommendations established in 2012 under the auspices of the National Cancer Institute (INCa)].Semantic proximity Read ↗

MUTYH-associated polyposis (MAP).Semantic proximity Read ↗

Prevalence and characteristics of MUTYH-associated polyposis in patients with multiple adenomatous and serrated polyps.Semantic proximity Read ↗

A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer.Semantic proximity Read ↗

First report of medulloblastoma in a patient with MUTYH-associated polyposis.Semantic proximity Read ↗

Phenotype Correlations With Pathogenic DNA Variants in the MUTYH Gene: A Review of Over 2000 CasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.