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Article

Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations.

Cancer letters - 18 Feb 2009

Tricarico Rossella, Bet Paola, Ciambotti Benedetta, Di Gregorio Carmela, Gatteschi Beatrice, Gismondi Viviana, Toschi Benedetta, Tonelli Francesco, Varesco Liliana, Genuardi Maurizio

Abstract excerpt

MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS ge...

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Source

Identifiers

PMID: 18980800
DOI: 10.1016/j.canlet.2008.09.022

Genes

MUTYH
KRAS
PTEN
APC
BRAF
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18980800-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations.PMID 18980800Read ↗

Endometrial cancer may be part of the MUTYH-associated polyposis cancer spectrum.Semantic proximity Read ↗

MUTYH Associated Polyposis (MAP)Semantic proximity Read ↗

Phenotype correlations with pathogenic DNA variants in the<i>MUTYH</i>geneSemantic proximity Read ↗

MUTYH-associated tumor syndrome: The other face of MAP.Semantic proximity Read ↗

Phenotype Correlations With Pathogenic DNA Variants in the MUTYH Gene: A Review of Over 2000 CasesSemantic proximity Read ↗

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.Semantic proximity Read ↗

[Inherited mutations of MUTYH and colorectal cancer].Semantic proximity Read ↗

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.Semantic proximity Read ↗

Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH.Semantic proximity Read ↗

Biallelic MUTYH mutations can mimic Lynch syndrome.Semantic proximity Read ↗

MUTYH-associated polyposis (MAP).Semantic proximity Read ↗

Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.Semantic proximity Read ↗

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