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Article

Model Identifies Genetic Predisposition of Alzheimer's Disease as Key Decider in Cell Susceptibility to Stress.

International journal of molecular sciences - 5 Nov 2021

Stefani Ioanna C, de Thé François-Xavier Blaudin, Kontoravdi Cleo, Polizzi Karen M

Abstract excerpt

Accumulation of unfolded/misfolded proteins in neuronal cells perturbs endoplasmic reticulum homeostasis, triggering a stress cascade called unfolded protein response (UPR), markers of which are upregulated in Alzheimer's disease (AD) brain specimens. We measured the UPR dynamic response in three human neuroblastoma cell lines overexpressing the wild-type and two familial AD (FAD)-associated mutant forms of...

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Identifiers

PMID: 34769426
DOI: 10.3390/ijms222112001
PMCID: PMC8584528

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