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Article

Involvement of C4 allotypes in the pathogenesis of human diseases.

Revista do Hospital das Clinicas - 1 Jun 2004

Samano Eliana Sueco Tibana, Ribeiro Lia de Melo, Gorescu Rosa G, Rocha Katya Cristina, Grumach Anete S

Abstract excerpt

The complement system is an important humoral defense mechanism that plays a relevant role against microbial agents, inflammatory response control, and immunocomplex clearance. Classical complement pathway activation is antibody-dependent. The C4 component participates in the initial step of activation, and C4 expression is determined by 2 pairs of allotypes: C4A and C4B. Deficiencies in C4 allotypes have been...

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Identifiers

PMID: 15286835
DOI: 10.1590/s0041-87812004000300009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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