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Article

Glucocorticoid receptor isoform‐specific regulation of development, circadian rhythm, and inflammation in mice

19 Apr 2018

Abstract excerpt

Glucocorticoids are primary stress hormones, and their synthetic derivatives are widely used clinically. The therapeutic efficacy of these steroids is limited by side effects and glucocorticoid resistance. Multiple glucocorticoid receptor (GR) isoforms are produced from a single gene by alternative translation initiation; however, the role individual isoforms play in tissue-specific responses to glucocorticoids...

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PMID: 29672221
DOI: 10.1096/fj.201701153r

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