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Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy

3 Jan 2017

Abstract excerpt

Pregnancy is one of the strongest inducers of immunological tolerance. Disease activity of many autoimmune diseases including multiple sclerosis (MS) is temporarily suppressed by pregnancy, but little is known about the underlying molecular mechanisms. Here, we investigated the endocrine regulation of conventional and regulatory T cells (Tregs) during reproduction. In vitro, we found the pregnancy hormone...

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PMID: 28049829
DOI: 10.1073/pnas.1617115114

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