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Article

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration

1 Jan 2014

Abstract excerpt

BACKGROUND: Defects in airway mucosal defense, including decreased mucus clearance, contribute to the pathogenesis of human chronic obstructive pulmonary diseases. Scnn1b-Tg mice, which exhibit chronic airway surface dehydration from birth, can be used as a model to study the pathogenesis of muco-obstructive lung disease across developmental stages. To identify molecular signatures associated with obstructive...

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PMID: 25204199
DOI: 10.1186/1471-2164-15-726

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