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Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problems

2025-11-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Neurodevelopmental disorders have been associated with hearing problems (HP) later in life, but there is limited information regarding their shared biology. <h4>Methods</h4> We leveraged large-scale genome-wide datasets to estimate genetic correlation (global and local), polygenic overlap, and locus-specific pleiotropy among HP, autism spectrum disorder (ASD), attention-def...

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Literature Corpus work
39657235-05fc-5655-b1e9-b015e2e8ae47
DOI
10.1101/2025.11.03.25339410
Open publication

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Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problemsDOI 10.1101/2025.11.03.25339410
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