Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment.

doi:10.1016/j.jaac.2017.11.013

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Article

Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment.

Journal of the American Academy of Child and Adolescent Psychiatry - 1 Feb 2018

Shadrin Alexey A, Smeland Olav B, Zayats Tetyana, Schork Andrew J, Frei Oleksandr, Bettella Francesco, Witoelar Aree, Li Wen, Eriksen Jon A, Krull Florian, Djurovic Srdjan, Faraone Stephen V, Reichborn-Kjennerud Ted, Thompson Wesley K, Johansson Stefan, Haavik Jan, Dale Anders M, Wang Yunpeng, Andreassen Ole A

Abstract excerpt

OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve discovery of ADHD-associated genetic variants and to investigate genetic overlap between these phenotypes. METHOD: A conditional/conjunctional false discovery rate (condFDR/conjFDR) method was...

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PMID: 29413154
DOI: 10.1016/j.jaac.2017.11.013
PMCID: PMC5806128

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