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Article

The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort.

Journal of clinical lipidology - 1 Jan 2000

Hoenig Michel R, Walker Philip J, Gurnsey Christine, Beadle Karen, Johnson Leslie

Abstract excerpt

OBJECTIVE: The CC genotype of the C3435T polymorphism in ABCB1 is associated with increased P-glycoprotein expression, reduced low-density lipoprotein cholesterol (LDL-C) response to atorvastatin, and a reduced area-under-the-curve in pharmacokinetic studies. We sought to assess the relationship between 1) genotype and Atorvastatin efficacy, independently of variation in cholesterol metabolism and 2) genotype and...

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Identifiers

PMID: 21392722
DOI: 10.1016/j.jacl.2011.01.001

Genes

ABCB1

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Related research

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The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort.PMID 21392722Read ↗

ABCB1 C3435T polymorphism and the lipid-lowering response in hypercholesterolemic patients on statins: a meta-analysis.Semantic proximity Read ↗

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Impact of SLCO1B1 (rs2306283) polymorphism on personalized atorvastatin dosing in a genetically distinct South Asian cohort.Semantic proximity Read ↗

Common genetic variation in the ABCB1 gene is associated with the cholesterol-lowering effect of simvastatin in males.Semantic proximity Read ↗

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