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The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis

10 Nov 2021

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of genomic instability associated with large number of genetic alterations. BRD4 is the 4th most amplified gene in HGSOC, which correlates with poor patients' prognosis. BRD4 is constitutively expressed and generates two proteins, BRD4 long (BRD4-L)...

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PMID: 34758842
DOI: 10.1186/s12943-021-01424-5

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