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Article

Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype.

Redox biology - 1 Oct 2024

Hussain Salik, Majumder Nairrita, Mazumder Md Habibul Hasan, Lewis Sara E, Olapeju Olanrewaju, Velayutham Murugesan, Amin Md Shahrier, Brundage Kathleen, Kelley Eric E, Vanoirbeek Jeroen

Abstract excerpt

The ability of air pollution to induce acute exacerbation of asthma is well documented. However, the ability of ozone (O3), the most reactive gaseous component of air pollution, to function as a modulator during sensitization is not well established. C57BL/6 J male mice were intranasally sensitized to house dust mite (HDM) (40 μg/kg) for 3 weeks on alternate days in parallel with once-a-week O3 exposure (1 ppm)....

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Identifiers

PMID: 39244793
DOI: 10.1016/j.redox.2024.103330
PMCID: PMC11407077

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