Article
Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants.
Science (New York, N.Y.) - 24 Dec 2021
McCallum Matthew, Walls Alexandra C, Sprouse Kaitlin R, Bowen John E, Rosen Laura E, Dang Ha V, De Marco Anna, Franko Nicholas, Tilles Sasha W, Logue Jennifer, Miranda Marcos C, Ahlrichs Margaret, Carter Lauren, Snell Gyorgy, Pizzuto Matteo Samuele, Chu Helen Y, Van Voorhis Wesley C, Corti Davide, Veesler David
Abstract excerpt
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the emergence of variants, including the B.1.617.2 (Delta) variant of concern that is causing a new wave of infections and has become globally dominant. We show that these variants dampen the in vitro potency of vaccine-elicited serum neutralizing antibodies and provide a structural framework for describing their immune evasion....
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