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Article

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

Blood - 15 Aug 2006

Rocnik Jennifer L, Okabe Rachel, Yu Jin-Chen, Lee Benjamin H, Giese Neill, Schenkein David P, Gilliland D Gary

Abstract excerpt

Acquired mutations in the FLT3 receptor tyrosine kinase are common in acute myeloid leukemia and result in constitutive activation. The most frequent mechanism of activation is disruption of the juxtamembrane autoregulatory domain by internal tandem duplications (ITDs). FLT3-ITDs confer factor-independent growth to hematopoietic cells and induce a myeloproliferative syndrome in murine bone marrow transplant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 16627759
DOI: 10.1182/blood-2005-11-011429
PMCID: PMC1895880

Genes

FLT3

Provenance

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Related research

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Research trail→

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Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.PMID 16627759Read ↗

Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potentialSemantic proximity Read ↗

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Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype.Semantic proximity Read ↗

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor.Semantic proximity Read ↗

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation.Semantic proximity Read ↗

Differential signaling of Flt3 activating mutations in acute myeloid leukemia: a working model.Semantic proximity Read ↗

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AMLSemantic proximity Read ↗

The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.Semantic proximity Read ↗

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Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.Semantic proximity Read ↗

Deletions in FLT-3 juxtamembrane domain define a new class of pathogenic mutations: case report and systematic analysis.Semantic proximity Read ↗

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