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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

19 Oct 2021

Abstract excerpt

Pathogenic viruses induce metabolic changes in host cells to secure the availability of biomolecules and energy to propagate. Influenza A virus (IAV) and severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) both infect the human airway epithelium and are important human pathogens. The metabolic changes induced by these viruses in a physiologically relevant human model and how this affects innate immune...

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PMID: 34746710
DOI: 10.1016/j.isci.2021.103300

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