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Article

Cytosine methylation by the SuaI restriction-modification system: implications for genetic fidelity in a hyperthermophilic archaeon.

Journal of bacteriology - 1 Aug 2003

Grogan Dennis W

Abstract excerpt

5-methylcytosine in chromosomal DNA represents a potential source of frequent spontaneous mutation for hyperthermophiles. To determine the relevance of this threat for the archaeon Sulfolobus acidocaldarius, the mode of GGCC methylation by its restriction-modification system, SuaI, was investigated. Distinct isoschizomers of the SuaI endonuclease were used to probe the methylation state of GGCC in native S....

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Identifiers

PMID: 12867480
DOI: 10.1128/JB.185.15.4657-4661.2003
PMCID: PMC165766

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Source receipt: pubmed, retrieved 7 Sept 2026.

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