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Aging of alveolar type 2 cells induced by Lonp1 deficiency exacerbates pulmonary fibrosis

16 Apr 2024

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive and chronic disease that significantly impacts patient quality of life, and its incidence is on the rise. The pathogenesis of IPF remains poorly understood. Alveolar type 2 (AT2) cells are crucial in the onset and progression of IPF, yet the specific mechanisms involved are not well defined. Lon protease 1 (LONP1), known for its critical roles in various...

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PMID: 38625722
DOI: 10.17305/bb.2024.10429

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