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Article

Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2021

Overs Bronwyn J, Roberts Gloria, Ridgway Kate, Toma Claudio, Hadzi-Pavlovic Dusan, Wilcox Holly C, Hulvershorn Leslie A, Nurnberger John I, Schofield Peter R, Mitchell Philip B, Fullerton Janice M

Abstract excerpt

Bipolar disorder (BD) is associated with a 20-30-fold increased suicide risk compared to the general population. First-degree relatives of BD patients show inflated rates of psychopathology including suicidal behaviors. As reliable biomarkers of suicide attempts (SA) are lacking, we examined associations between suicide-related polygenic risk scores (PRSs)-a quantitative index of genomic risk-and variability in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34726322
DOI: 10.1002/ajmg.b.32879

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