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Article

Association of Polygenic Risk Score for Suicidal Behavior With Ventral Prefrontal Morphology in Bipolar Disorder.

Bipolar disorders - 1 Nov 2026

Katz Shroitman Noa, Levey Daniel F, Pittman Brian, Zheng Suchen, Quatrano Susan, Sankar Anjali, Colic Lejla, Gelernter Joel, Willour Virginia L, Blumberg Hilary P

Abstract excerpt

BACKGROUND: Bipolar disorder (BD) studies consistently implicate the ventral prefrontal cortex (VPFC) in association with suicidal behaviors. A suicidal behavior polygenic risk score (PRS) can now be computed to test whether elevated genetic risk for suicidal behavior is associated with variation in VPFC gray matter and/or suicidal behavior history. METHODS: We explored relationships among a PRS previously...

Read the complete abstract on PubMed

Topics

Humans
Bipolar Disorder
Female
Prefrontal Cortex
Genetic Risk Score
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Suicide, Attempted

Male

Multifactorial Inheritance

Young Adult

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42713711
DOI: 10.1111/bdi.70172
PMCID: PMC13555509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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