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Article

The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.

Clinical pharmacology and therapeutics - 1 Mar 2022

Dinh Jean C, Boone Erin C, Staggs Vincent S, Pearce Robin E, Wang Wendy Y, Gaedigk Roger, Leeder James Steven, Gaedigk Andrea

Abstract excerpt

rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant "enhancer" single nucleotide polymorphism (SNP), our goal was to further assess the impact of rs5758550 on CYP2D6 activity toward two probe substrates, atomoxetine (ATX) and dextromethorphan (DM), using in vivo urinary...

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Identifiers

PMID: 34716917
DOI: 10.1002/cpt.2469
PMCID: PMC8825689

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