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Article

Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.

Human molecular genetics - 1 Jan 2014

Wang Danxin, Poi Ming J, Sun Xiaochun, Gaedigk Andrea, Leeder J Steven, Sadee Wolfgang

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of 25% of clinically used drugs. Genetic polymorphisms cause substantial variation in CYP2D6 activity and serve as biomarkers guiding drug therapy. However, genotype-phenotype relationships remain ambiguous except for poor metabolizers carrying null alleles, suggesting the presence of yet unknown genetic variants. Searching for regulatory CYP2D6...

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PMID: 23985325
DOI: 10.1093/hmg/ddt417
PMCID: PMC3857955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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