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Article

Distribution and linkage disequilibrium of the enhancer SNP rs5758550 among Latin American populations: influence of continental ancestry.

Pharmacogenetics and genomics - 1 Jun 2020

Elias Anna Beatriz Ribeiro, Araújo Gilderlanio Santana de, de Souza Sandro José, Suarez-Kurtz Guilherme

Abstract excerpt

OBJECTIVES: A single nucleotide polymorphism (SNP), rs5758550, in a critical enhancer region downstream of the CYP2D6 promoter was proposed to modulate CYP2D6 activity, depending on its linkage disequilibrium (LD) with the common CYP2D6 SNP, rs16947. We examined the influence of individual biogeographical ancestry on the frequency distribution of rs5758550 and its LD with rs16947 in Latin American populations. We...

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PMID: 32187157
DOI: 10.1097/FPC.0000000000000398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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