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Article

Taming the Wild-Type Gastrointestinal Stromal Tumor: Improved Tissue Culture.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2022

Blakely Andrew M, Glod John W, Wedekind Malone Mary Frances

Abstract excerpt

Wild-type gastrointestinal stromal tumors (WT GIST) are most frequently characterized by succinate dehydrogenase (SDH) deficiency. Reliable ex vivo tumor models have been difficult to develop given the downstream metabolic effects of SDH deficiency. Improved tumor modeling approaches are needed to develop effective systemic treatment options for patients with WT GIST.See related article by Yebra et al., p. 187.

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Identifiers

PMID: 34711630
DOI: 10.1158/1078-0432.CCR-21-3409
PMCID: PMC8738134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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