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Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

2022-01-26

Abstract excerpt

<h4>Summary</h4> Immunization with SARS-CoV-2 spike elicits diverse antibodies, but can any of these neutralize broadly? Here, we report the isolation and characterization of antibody WS6, from a mouse immunized with mRNA encoding the SARS-CoV-2 spike. WS6 bound diverse beta-coronavirus spikes and neutralized SARS-CoV-2 variants, SARS-CoV, and related sarbecoviruses. Epitope mapping revealed WS6 to target a regio...

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Identifiers and source

Literature Corpus work
be1dd0f8-f2e1-5ffc-8d3e-98d24421589c
DOI
10.1101/2022.01.25.477770
Open publication

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Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerabilityDOI 10.1101/2022.01.25.477770
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