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Article

Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis.

Journal of epidemiology and community health - 1 Apr 2022

Scannell Bryan Molly, Ogundiran Temidayo, Ojengbede Oladosu, Zheng Wei, Blot William, Domcheck Susan, Hennis Anselm, Nemesure Barbara, Ambs Stefan, Olopade Olufunmilayo I, Huo Dezheng

Abstract excerpt

INTRODUCTION: Many diseases of adulthood are associated with a woman's age at menarche. Genetic variation affects age at menarche, but it remains unclear whether in women of African ancestry the timing of menarche is regulated by genetic variants that were identified in predominantly European and East Asian populations. METHODS: We explored the genetic architecture of age at menarche in 3145 women of African...

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PMID: 34706928
DOI: 10.1136/jech-2020-216000
PMCID: PMC9011920

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