Article
Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study.
Journal of ovarian research - 7 May 2024
Gao Bingrui, Zhang Chenxi, Wang Deping, Li Bojuan, Shan Zhongyan, Teng Weiping, Li Jing
Abstract excerpt
BACKGROUND: Recent studies have revealed the correlation between serum vitamin D (VD) level and polycystic ovary syndrome (PCOS), but the causality and specific mechanisms remain uncertain. OBJECTIVE: We aimed to investigate the cause-effect relationship between serum VD and PCOS, and the role of testosterone in the related pathological mechanisms. METHODS: We assessed the causality between serum VD and PCOS by...
Topics
- Polycystic Ovary Syndrome
- Humans
- Female
- Mendelian Randomization Analysis
- Vitamin D
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide
- Testosterone
- Genetic Predisposition to Disease
- Vitamin D Deficiency