Article
Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients.
Genetic epidemiology - 1 Jan 2011
Manning Alisa K, LaValley Michael, Liu Ching-Ti, Rice Kenneth, An Ping, Liu Yongmei, Miljkovic Iva, Rasmussen-Torvik Laura, Harris Tamara B, Province Michael A, Borecki Ingrid B, Florez Jose C, Meigs James B, Cupples L Adrienne, Dupuis Josée
Abstract excerpt
INTRODUCTION: Genetic discoveries are validated through the meta-analysis of genome-wide association scans in large international consortia. Because environmental variables may interact with genetic factors, investigation of differing genetic effects for distinct levels of an environmental exposure in these large consortia may yield additional susceptibility loci undetected by main effects analysis. We describe a...
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