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Article

Abnormal paraoxonase-1 (PON1) enzyme activity in idiopathic inflammatory myopathies.

Rheumatology (Oxford, England) - 30 May 2022

Bae Sangmee Sharon, Shahbazian Ani, Wang Jennifer, Golub Ilana, Oganesian Buzand, Dowd Tyler, Vayngortin Beata, Wang Ryan, Elashoff David, Reddy Srinivasa T, Charles-Schoeman Christina

Abstract excerpt

OBJECTIVES: Patients with idiopathic inflammatory myopathies (IIM) have severe vascular involvement, which contributes to disease morbidity and mortality. Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL) associated protein that protects the vascular endothelium from oxidative injury and damage. The current work assessed the functional and genetic determinants of PON1 activity in IIM patients. METHODS: A...

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Identifiers

PMID: 34698804
DOI: 10.1093/rheumatology/keab795
PMCID: PMC9308379

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