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Article

Scalable Reconstruction of SARS-CoV-2 Phylogeny with Recurrent Mutations.

Journal of computational biology : a journal of computational molecular cell biology - 1 Nov 2021

Novikov Daniel, Knyazev Sergey, Grinshpon Mark, Icer Pelin, Skums Pavel, Zelikovsky Alex

Abstract excerpt

This article presents a novel scalable character-based phylogeny algorithm for dense viral sequencing data called SPHERE (Scalable PHylogEny with REcurrent mutations). The algorithm is based on an evolutionary model where recurrent mutations are allowed, but backward mutations are prohibited. The algorithm creates rooted character-based phylogeny trees, wherein all leaves and internal nodes are labeled by...

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Identifiers

PMID: 34698524
DOI: 10.1089/cmb.2021.0306
PMCID: PMC8819518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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