Article
Respiratory Syncytial Virus Matrix Protein-Chromatin Association Is Key to Transcriptional Inhibition in Infected Cells.
Cells - 18 Oct 2021
Li Hong-Mei, Ghildyal Reena, Hu Mengjie, Tran Kim C, Starrs Lora M, Mills John, Teng Michael N, Jans David A
Abstract excerpt
The morbidity and mortality caused by the globally prevalent human respiratory pathogen respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously demonstrated that the RSV matrix (M) protein shuttles, in signal-dependent fashion, between host cell nucleus and cytoplasm, and that this trafficking is central to RSV replication and assembly. Here we analyze in detail the nuclear role...
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