Article

An Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

2024-10-16

Abstract excerpt

The global burden of respiratory syncytial virus (RSV) and severe associated disease is prodigious. RSV specific vaccines have been launched recently but there is no antiviral medicine commercially available. RSV polymerase (L) protein is one of the promising antiviral targets along with fusion and nucleocapsid proteins. During medicinal chemis-try campaign, two potent L-protein inhibitors (PC786 and PC751) were i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2d06fb3-6663-584b-87ed-f5cf4a9819e8
DOI: 10.20944/preprints202410.1267.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial VirusDOI 10.20944/preprints202410.1267.v1Read

Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus.Semantic proximity Read

Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping ActivitiesSemantic proximity Read

Tetramerization of Phosphoprotein Is Essential for Respiratory Syncytial Virus Budding while Its N-Terminal Region Mediates Direct Interactions with the Matrix ProteinSemantic proximity Read

The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 associationSemantic proximity Read

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymeraseSemantic proximity Read

Respiratory Syncytial Virus Matrix Protein-Chromatin Association Is Key to Transcriptional Inhibition in Infected Cells.Semantic proximity Read

Structure-guided design of small-molecule therapeutics against RSV diseaseSemantic proximity Read

Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604Semantic proximity Read

Host cytoskeleton in respiratory syncytial virus assembly and buddingSemantic proximity Read

New Host Factors Important for Respiratory Syncytial Virus (RSV) Replication Revealed by a Novel Microfluidics Screen for Interactors of Matrix (M) Protein*Semantic proximity Read

Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial VirusSemantic proximity Read

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerasesSemantic proximity Read